RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans
Kuhn, T.P., Spivak, N.M., Dang, B.H., Becerra, S., Halavi, S., Rotstein, N., Rosenberg, B., Hiller, S.J., Swenson, A., Cvijanovic, L., Dang, N., Sun, M., Kronemyer, D., Berlow, R., Revett, M.R., Suthana, N., Monti, M., Bookheimer, S.Y.
Connectivity-based parcellation of the amygdala and identification of its main white matter connections.
Avecillas-Chasin, J. M., Levinson, S., Kuhn, T., Omidbeigi, M., Langevin, J. P., Pouratian, N., & Bari, A. (2023). Scientific reports, 13(1), 1305.
Asylum Medicine Training Initiative: Asylum Medicine Introductory Curriculum
Saadi A., Khoury M., Dietiker C., Mass A., Jacquemet N., & Kuhn T. (2022). Module 8: Traumatic Brain Injury. In Emery E., DeFries T. (2022). Panopto. https://pro.panopto.com/Panopto/Pages/Viewer.aspx?tid=9009e2b9-7ae6-4b7b- 91e0-aed80111c48e
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series
Rindner, E., Haroon, J., Jordan, K., Mahdavi, K., Surya, J. R., Zielinski, M., Habelhah, B., Venkatraman, V., Becerra, S., Chan, L., Kuhn, T., & Jordan, S. (2022). Journal of Lasers in Medical Sciences, 13, e65.
Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study
Zielinski, M. A., Evans, N. E., Bae, H., Kamrava, E., Calodney, A., Remley, K., ... & Jordan, S. (2022). Pain Physician, 25(1), 29.
A Structural Connectivity Atlas of Limbic Brainstem Nuclei
Levinson, S., Miller, M., Iftekhar, A., Arriola, D., Hazany, S., Avecillas-Chasin, J., ... & Bari, A. A. (2022). bioRxiv.
Intraindividual Variability in Neuropsychological Performance Predicts Longitudinal Cortical Volume Loss in Early Parkinson’s Disease
Jones, J. D., Valenzuela, Y. G., Uribe, C., Bunch, J., & Kuhn, T. P. Neuropsychology.
The Role of the Insula in Classical and Dissociative PTSD: A Double Case Study
Blades, R., Becerra, S., Jordan, S., Eusebio, B., Heatwole, M., Iovine, J., ... & Kuhn, T. (2022). Neurocase, 1-9.
A Systematic Approach to Neuropsychiatric Intervention: Functional Neuroanatomy Underlying Symptom Domains as Targets for Treatment
Kuhn, T., Haroon, J., & Spivak, N. M. (2022). Focus, 20(1), 45-54.
Ultrasound as a Neurotherapeutic: A Circuit-and System-Based Interrogation
Spivak, N. M., Tyler, W. J., Bari, A. A., & Kuhn, T. P. (2022). Focus, 20(1), 32-35.
Noninvasive Delivery of Biologicals to the Brain
Jordan, S., Zielinski, M., Kortylewski, M., Kuhn, T., & Bystritsky, A. (2022). Focus, 20(1), 64-70.
Translating State-of-the-art Brain Magnetic Resonance Imaging (MRI) Techniques into Clinical Practice: Multimodal MRI Differentiates Dementia Subtypes in a Traditional Clinical Setting
Kuhn, T., Becerra, S., Duncan, J., Spivak, N., Dang, B. H., Habelhah, B., ... & Jordan, S. E. (2021). Quantitative Imaging in Medicine and Surgery, 11(9), 4056.
Neuroanatomical Differences in the Memory Systems of Intellectual Giftedness and Typical Development
Kuhn, T., Blades, R., Gottlieb, L., Knudsen, K., Ashdown, C., Martin‐Harris, L., ... & Bookheimer, S. Y. (2021). Brain and Behavior, 11(11), e2348.
Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy
Stern JM, Spivak NM, Becerra S, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, & Bystritsky A. (2021). Brain Stimulation.
Histological Examination of Transcranial Focused Ultrasound Effects on Human Brain Tissue
Spivak NM, Korb AS, Reyes SD, Bych BP, Schafer SF, Khanlou N, Johnson EA, Schafer ME, Cohen MS, Kuhn T, & Bystritsky A. Brain Stimulation. 2021; 14(6):1486-8. DOI: 10.1016/j.brs.2021.09.015. PubMed PMID: 34607066
A Pilot Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder
Mahdavi, K., Jordan, S., Habelhah, B., Zielinski, M., Haroon, J., Becerra, S., ... & Kuhn, T. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1627.
A Case Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder and Major Depressive Disorder
Zielinski, M., Mahdavi, K., Jordan, S., Haroon, J., Habelhah, B., Beccera, S., ... & Kuhn, T. Bystrisky, A. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1667.
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Mahdavi, K. D., Jordan, S. E., Barrows, H. R., Pravdic, M., Habelhah, B., Evans, N. E., ... & Kuhn, T. (2021). Neurology: Clinical Practice, 11(3), e294-e302.
A case of COVID-encephalopathy imaged with fMRI and treated with near infrared light
Haroon, J., Mahdavi, K., Zielinski, M. A., Habelhah, B., Chan, L., Bystritsky, A., ... & Jordan, S. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation.