RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Effects of social adversity and HIV on subcortical shape and neurocognitive function
Thames, A. D., Kuhn, T. P., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2018). Brain imaging and behavior.
Effects of fMRI navigated TMS on treatment outcomes in major depressive disorder
Packham, H.R. & Nicodemus, N.E. & Jordan, S.E. & Whitney, M. & Pereles, F.S. & Duncan, J.C. & Becerra, S.B. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.
Utilizing fMRI correlates of cognitive reappraisal to identify additional TMS targets for the treatment of GAD
Nicodemus, N.E. & Packham, H.R. & Jordan, S.E. & Whitney, M. & Pereles, S. & Duncan, J.C. & Becerra, S.A. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.
Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV
Anderson AE, Jones JD, Thaler NS, Kuhn TP, Singer EJ, Hinkin CH. (2018). Neuropsychology.
An Augmented Aging Process in Brain White Matter in HIV
Kuhn, T., Kaufmann, T., Doan, N.T., Westlye, L.T., Jones, J., Nunez, R.A., Bookheimer, S.Y., Singer, E.J., Hinkin, C.H., Thames, A.D. (2018). Human Brain Mapping.
Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort
Jones, J. D., Kuhn, T. P., & Szymkowicz, S. M. (2018). Parkinsonism & related disorders.