RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans
Kuhn, T.P., Spivak, N.M., Dang, B.H., Becerra, S., Halavi, S., Rotstein, N., Rosenberg, B., Hiller, S.J., Swenson, A., Cvijanovic, L., Dang, N., Sun, M., Kronemyer, D., Berlow, R., Revett, M.R., Suthana, N., Monti, M., Bookheimer, S.Y.
Ultrasound as a Neurotherapeutic: A Circuit-and System-Based Interrogation
Spivak, N. M., Tyler, W. J., Bari, A. A., & Kuhn, T. P. (2022). Focus, 20(1), 32-35.
Noninvasive Delivery of Biologicals to the Brain
Jordan, S., Zielinski, M., Kortylewski, M., Kuhn, T., & Bystritsky, A. (2022). Focus, 20(1), 64-70.
Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy
Stern JM, Spivak NM, Becerra S, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, & Bystritsky A. (2021). Brain Stimulation.
Histological Examination of Transcranial Focused Ultrasound Effects on Human Brain Tissue
Spivak NM, Korb AS, Reyes SD, Bych BP, Schafer SF, Khanlou N, Johnson EA, Schafer ME, Cohen MS, Kuhn T, & Bystritsky A. Brain Stimulation. 2021; 14(6):1486-8. DOI: 10.1016/j.brs.2021.09.015. PubMed PMID: 34607066
A Pilot Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder
Mahdavi, K., Jordan, S., Habelhah, B., Zielinski, M., Haroon, J., Becerra, S., ... & Kuhn, T. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1627.
A Case Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder and Major Depressive Disorder
Zielinski, M., Mahdavi, K., Jordan, S., Haroon, J., Habelhah, B., Beccera, S., ... & Kuhn, T. Bystrisky, A. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1667.
Focused ultrasound as a potential means of facilitated exosome delivery to brodmann area 25 in the treatment of refractory depression
Mahdavi, Kennedy & Packham, H. & Nicodemus, N. & Jordan, S. & Iovine, J. & Duncan, J. & Becerra, S. & Spivak, Norman & Kuhn, Taylor & Whitney, M. & Mamoun, Michael. (2019). Brain Stimulation.
Variations in targeting techniques of focused ultrasound for use in neuromodulation
Spivak, N. M., & Kuhn, T. P. (2019). Brain stimulation.
Focused transcranial ultrasound for treatment of neurodegenerative dementia
Nicodemus, N. E., Becerra, S., Kuhn, T. P., Packham, H. R., Duncan, J., Mahdavi, K., ... & Jordan, S. Alzheimer's & Dementia: Translational Research & Clinical Interventions. (2019)