RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans
Kuhn, T.P., Spivak, N.M., Dang, B.H., Becerra, S., Halavi, S., Rotstein, N., Rosenberg, B., Hiller, S.J., Swenson, A., Cvijanovic, L., Dang, N., Sun, M., Kronemyer, D., Berlow, R., Revett, M.R., Suthana, N., Monti, M., Bookheimer, S.Y.
Connectivity-based parcellation of the amygdala and identification of its main white matter connections.
Avecillas-Chasin, J. M., Levinson, S., Kuhn, T., Omidbeigi, M., Langevin, J. P., Pouratian, N., & Bari, A. (2023). Scientific reports, 13(1), 1305.
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series
Rindner, E., Haroon, J., Jordan, K., Mahdavi, K., Surya, J. R., Zielinski, M., Habelhah, B., Venkatraman, V., Becerra, S., Chan, L., Kuhn, T., & Jordan, S. (2022). Journal of Lasers in Medical Sciences, 13, e65.
A Structural Connectivity Atlas of Limbic Brainstem Nuclei
Levinson, S., Miller, M., Iftekhar, A., Arriola, D., Hazany, S., Avecillas-Chasin, J., ... & Bari, A. A. (2022). bioRxiv.
Intraindividual Variability in Neuropsychological Performance Predicts Longitudinal Cortical Volume Loss in Early Parkinson’s Disease
Jones, J. D., Valenzuela, Y. G., Uribe, C., Bunch, J., & Kuhn, T. P. Neuropsychology.
Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV
Nir, T. M., Fouche, J. P., Ananworanich, J., Ances, B. M., Boban, J., Brew, B. J., ... & Jahanshad, N. (2021). JAMA network open.
The Effects of HIV and Aging on Subcortical Shape Alterations: A 3D Morphometric Study.
Kuhn, T.,Schonfeld, D., Sayegh, P., Jones, J.D., Arentoft, A., Hinkin, C.H., Bookheimer, S.Y., & Thames, A.D. (2016). Human Brain Mapping. DOI 10.1002/hbm.23436