RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Episodic and Semantic Memory Disorders
Bauer R.M., Gaynor L., Moreno C., Kuhn T. (2019). In: Ravdin L., Katzen H. (eds) Handbook on the Neuropsychology of Aging and Dementia. Clinical Handbooks in Neuropsychology.
Case report: Improved rTMS efficacy after fMRI localizes DLPFC target to non-dominant hemisphere
Iovine, J. & Spivak, Norman & Jordan, S. & Mahdavi, Kennedy & Duncan, J. & Becerra, S. & Packham, H. & Nicodemus, N. & Pereles, S. & Whitney, M. & Bystrisky, A. & Kuhn, Taylor & Mamoun, Michael. (2019). Brain Stimulation.
Focused ultrasound as a potential means of facilitated exosome delivery to brodmann area 25 in the treatment of refractory depression
Mahdavi, Kennedy & Packham, H. & Nicodemus, N. & Jordan, S. & Iovine, J. & Duncan, J. & Becerra, S. & Spivak, Norman & Kuhn, Taylor & Whitney, M. & Mamoun, Michael. (2019). Brain Stimulation.
Effects of Diffusion MRI Model and Harmonization on the Consistency of Findings in an International Multi-cohort HIV Neuroimaging Study.
Nir, T. M., Lam, H. Y., Ananworanich, J., Boban, J., Brew, B. J., Cysique, L., Fouche, J. P., Kuhn, T., Porges, E. S., Law, M., Paul, R. H., Thames, A., Woods, A. J., Valcour, V. G., Thompson, P. M., Cohen, R. A., Stein, D. J., & Jahanshad, N. (2019). Computational Diffusion MRI .
Variations in targeting techniques of focused ultrasound for use in neuromodulation
Spivak, N. M., & Kuhn, T. P. (2019). Brain stimulation.
Focused transcranial ultrasound for treatment of neurodegenerative dementia
Nicodemus, N. E., Becerra, S., Kuhn, T. P., Packham, H. R., Duncan, J., Mahdavi, K., ... & Jordan, S. Alzheimer's & Dementia: Translational Research & Clinical Interventions. (2019)
Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort
Jones JD, Kurniadi NE, Kuhn TP, Szymkowicz SM, Bunch J, Rahmani E. (2019). Neuropsychology.
Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study
Jones JD, Kuhn T, Levine A, Sacktor N, Munro CA, Teplin LA, D'Souza G, Martin EM, Becker JT, Miller EN, Hinkin CH. (2019). Neuropsychology.
The Lifespan Human Connectome Project in Aging: An overview.
Bookheimer SY, Salat DH, Terpstra M, Ances BM, Barch DM, Buckner RL, Burgess GC, Curtiss SW, Diaz-Santos M, Elam JS, Fischl B, Greve DN, Hagy HA, Harms MP, Hatch OM, Hedden T, Hodge C, Japardi KC, Kuhn TP, Ly TK, Smith SM, Somerville LH, Uğurbil K, van der Kouwe A, Van Essen D, Woods RP, Yacoub E. (2019). Neuroimage.