RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Asylum Medicine Training Initiative: Asylum Medicine Introductory Curriculum
Saadi A., Khoury M., Dietiker C., Mass A., Jacquemet N., & Kuhn T. (2022). Module 8: Traumatic Brain Injury. In Emery E., DeFries T. (2022). Panopto. https://pro.panopto.com/Panopto/Pages/Viewer.aspx?tid=9009e2b9-7ae6-4b7b- 91e0-aed80111c48e
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series
Rindner, E., Haroon, J., Jordan, K., Mahdavi, K., Surya, J. R., Zielinski, M., Habelhah, B., Venkatraman, V., Becerra, S., Chan, L., Kuhn, T., & Jordan, S. (2022). Journal of Lasers in Medical Sciences, 13, e65.
Intraindividual Variability in Neuropsychological Performance Predicts Longitudinal Cortical Volume Loss in Early Parkinson’s Disease
Jones, J. D., Valenzuela, Y. G., Uribe, C., Bunch, J., & Kuhn, T. P. Neuropsychology.
A Systematic Approach to Neuropsychiatric Intervention: Functional Neuroanatomy Underlying Symptom Domains as Targets for Treatment
Kuhn, T., Haroon, J., & Spivak, N. M. (2022). Focus, 20(1), 45-54.
Translating State-of-the-art Brain Magnetic Resonance Imaging (MRI) Techniques into Clinical Practice: Multimodal MRI Differentiates Dementia Subtypes in a Traditional Clinical Setting
Kuhn, T., Becerra, S., Duncan, J., Spivak, N., Dang, B. H., Habelhah, B., ... & Jordan, S. E. (2021). Quantitative Imaging in Medicine and Surgery, 11(9), 4056.
Neuroanatomical Differences in the Memory Systems of Intellectual Giftedness and Typical Development
Kuhn, T., Blades, R., Gottlieb, L., Knudsen, K., Ashdown, C., Martin‐Harris, L., ... & Bookheimer, S. Y. (2021). Brain and Behavior, 11(11), e2348.
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Mahdavi, K. D., Jordan, S. E., Barrows, H. R., Pravdic, M., Habelhah, B., Evans, N. E., ... & Kuhn, T. (2021). Neurology: Clinical Practice, 11(3), e294-e302.
A case of COVID-encephalopathy imaged with fMRI and treated with near infrared light
Haroon, J., Mahdavi, K., Zielinski, M. A., Habelhah, B., Chan, L., Bystritsky, A., ... & Jordan, S. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation.
Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort
Jones JD, Kurniadi NE, Kuhn TP, Szymkowicz SM, Bunch J, Rahmani E. (2019). Neuropsychology.
Effects of social adversity and HIV on subcortical shape and neurocognitive function
Thames, A. D., Kuhn, T. P., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2018). Brain imaging and behavior.
Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV
Anderson AE, Jones JD, Thaler NS, Kuhn TP, Singer EJ, Hinkin CH. (2018). Neuropsychology.
Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort
Jones, J. D., Kuhn, T. P., & Szymkowicz, S. M. (2018). Parkinsonism & related disorders.
Assessment of grammar optimizes language tasks for the intracarotid amobarbital procedure
Połczyńska M, Kuhn T, You SC, Walshaw P, Curtiss S, Bookheimer S. (2017). Epilepsy Behav.
Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults
Thames, A. D., Kuhn, T., Williamson, T. J., Jones, J. D., Mahmood, Z., & Hammond, A. (2017). Drug and Alcohol Dependence.
Effects of Social Adversity and HIV on Subcortical Shape and Neurocognitive Function
Thames, A. D., Kuhn, T., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2017). Brain Imaging and Behavior.
Longitudinal Intra-Individual Variability in Neuropsychological Performance Relates to White Matter Changes in HIV
Jones, J. D., Kuhn, T., Mahmood, Z., Singer, E. J., Hinkin, C. H., Thames, A. D. (2017). Neuropsychology.
Mild Cognitive Impairment is Associated with White Matter Integrity Changes in Late-Myelinating Regions within the Corpus Callosum
Stricker, N., Salat, D. H., Kuhn, T., Foley, J. M., Price, J. S., Westlye, L. T., Esterman, M. S., McGlinchey, R. E., Milberg, W. P. Leritz, E. C. (2015). American Journal of Alzheimer’s Disease and Other Dementias.