RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans
Kuhn, T.P., Spivak, N.M., Dang, B.H., Becerra, S., Halavi, S., Rotstein, N., Rosenberg, B., Hiller, S.J., Swenson, A., Cvijanovic, L., Dang, N., Sun, M., Kronemyer, D., Berlow, R., Revett, M.R., Suthana, N., Monti, M., Bookheimer, S.Y.
Connectivity-based parcellation of the amygdala and identification of its main white matter connections.
Avecillas-Chasin, J. M., Levinson, S., Kuhn, T., Omidbeigi, M., Langevin, J. P., Pouratian, N., & Bari, A. (2023). Scientific reports, 13(1), 1305.
A Structural Connectivity Atlas of Limbic Brainstem Nuclei
Levinson, S., Miller, M., Iftekhar, A., Arriola, D., Hazany, S., Avecillas-Chasin, J., ... & Bari, A. A. (2022). bioRxiv.
Intraindividual Variability in Neuropsychological Performance Predicts Longitudinal Cortical Volume Loss in Early Parkinson’s Disease
Jones, J. D., Valenzuela, Y. G., Uribe, C., Bunch, J., & Kuhn, T. P. Neuropsychology.
The Role of the Insula in Classical and Dissociative PTSD: A Double Case Study
Blades, R., Becerra, S., Jordan, S., Eusebio, B., Heatwole, M., Iovine, J., ... & Kuhn, T. (2022). Neurocase, 1-9.
A Systematic Approach to Neuropsychiatric Intervention: Functional Neuroanatomy Underlying Symptom Domains as Targets for Treatment
Kuhn, T., Haroon, J., & Spivak, N. M. (2022). Focus, 20(1), 45-54.
Ultrasound as a Neurotherapeutic: A Circuit-and System-Based Interrogation
Spivak, N. M., Tyler, W. J., Bari, A. A., & Kuhn, T. P. (2022). Focus, 20(1), 32-35.
Translating State-of-the-art Brain Magnetic Resonance Imaging (MRI) Techniques into Clinical Practice: Multimodal MRI Differentiates Dementia Subtypes in a Traditional Clinical Setting
Kuhn, T., Becerra, S., Duncan, J., Spivak, N., Dang, B. H., Habelhah, B., ... & Jordan, S. E. (2021). Quantitative Imaging in Medicine and Surgery, 11(9), 4056.
Neuroanatomical Differences in the Memory Systems of Intellectual Giftedness and Typical Development
Kuhn, T., Blades, R., Gottlieb, L., Knudsen, K., Ashdown, C., Martin‐Harris, L., ... & Bookheimer, S. Y. (2021). Brain and Behavior, 11(11), e2348.
Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy
Stern JM, Spivak NM, Becerra S, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, & Bystritsky A. (2021). Brain Stimulation.
Histological Examination of Transcranial Focused Ultrasound Effects on Human Brain Tissue
Spivak NM, Korb AS, Reyes SD, Bych BP, Schafer SF, Khanlou N, Johnson EA, Schafer ME, Cohen MS, Kuhn T, & Bystritsky A. Brain Stimulation. 2021; 14(6):1486-8. DOI: 10.1016/j.brs.2021.09.015. PubMed PMID: 34607066
A case of COVID-encephalopathy imaged with fMRI and treated with near infrared light
Haroon, J., Mahdavi, K., Zielinski, M. A., Habelhah, B., Chan, L., Bystritsky, A., ... & Jordan, S. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation.
Tumor location and reduction in functional MRI estimates of language laterality
Połczyńska MM, Beck L, Kuhn T, Benjamin CF, Ly TK, Japardi K, Cavanagh L, Bookheimer SY. (2021). J Neurosurg.
Treating Dissociative Post-Traumatic Stress Disorder Presenting as a Functional Movement Disorder with Transcranial Magnetic Stimulation targeting the Cingulate Gyrus
Blades, R., Jordan, S., Becerra, S., Eusebio, B., Heatwole, M., Iovine, J., ... & Kuhn, T. (2020). Neurological Sciences, 41(8), 2275-2280.
Case report: Improved rTMS efficacy after fMRI localizes DLPFC target to non-dominant hemisphere
Iovine, J. & Spivak, Norman & Jordan, S. & Mahdavi, Kennedy & Duncan, J. & Becerra, S. & Packham, H. & Nicodemus, N. & Pereles, S. & Whitney, M. & Bystrisky, A. & Kuhn, Taylor & Mamoun, Michael. (2019). Brain Stimulation.
Focused ultrasound as a potential means of facilitated exosome delivery to brodmann area 25 in the treatment of refractory depression
Mahdavi, Kennedy & Packham, H. & Nicodemus, N. & Jordan, S. & Iovine, J. & Duncan, J. & Becerra, S. & Spivak, Norman & Kuhn, Taylor & Whitney, M. & Mamoun, Michael. (2019). Brain Stimulation.
Effects of Diffusion MRI Model and Harmonization on the Consistency of Findings in an International Multi-cohort HIV Neuroimaging Study.
Nir, T. M., Lam, H. Y., Ananworanich, J., Boban, J., Brew, B. J., Cysique, L., Fouche, J. P., Kuhn, T., Porges, E. S., Law, M., Paul, R. H., Thames, A., Woods, A. J., Valcour, V. G., Thompson, P. M., Cohen, R. A., Stein, D. J., & Jahanshad, N. (2019). Computational Diffusion MRI .
Focused transcranial ultrasound for treatment of neurodegenerative dementia
Nicodemus, N. E., Becerra, S., Kuhn, T. P., Packham, H. R., Duncan, J., Mahdavi, K., ... & Jordan, S. Alzheimer's & Dementia: Translational Research & Clinical Interventions. (2019)
Effects of fMRI navigated TMS on treatment outcomes in major depressive disorder
Packham, H.R. & Nicodemus, N.E. & Jordan, S.E. & Whitney, M. & Pereles, F.S. & Duncan, J.C. & Becerra, S.B. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.
Utilizing fMRI correlates of cognitive reappraisal to identify additional TMS targets for the treatment of GAD
Nicodemus, N.E. & Packham, H.R. & Jordan, S.E. & Whitney, M. & Pereles, S. & Duncan, J.C. & Becerra, S.A. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.