RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Translating State-of-the-art Brain Magnetic Resonance Imaging (MRI) Techniques into Clinical Practice: Multimodal MRI Differentiates Dementia Subtypes in a Traditional Clinical Setting
Kuhn, T., Becerra, S., Duncan, J., Spivak, N., Dang, B. H., Habelhah, B., ... & Jordan, S. E. (2021). Quantitative Imaging in Medicine and Surgery, 11(9), 4056.
Neuroanatomical Differences in the Memory Systems of Intellectual Giftedness and Typical Development
Kuhn, T., Blades, R., Gottlieb, L., Knudsen, K., Ashdown, C., Martin‐Harris, L., ... & Bookheimer, S. Y. (2021). Brain and Behavior, 11(11), e2348.
Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy
Stern JM, Spivak NM, Becerra S, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, & Bystritsky A. (2021). Brain Stimulation.
Histological Examination of Transcranial Focused Ultrasound Effects on Human Brain Tissue
Spivak NM, Korb AS, Reyes SD, Bych BP, Schafer SF, Khanlou N, Johnson EA, Schafer ME, Cohen MS, Kuhn T, & Bystritsky A. Brain Stimulation. 2021; 14(6):1486-8. DOI: 10.1016/j.brs.2021.09.015. PubMed PMID: 34607066
A Pilot Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder
Mahdavi, K., Jordan, S., Habelhah, B., Zielinski, M., Haroon, J., Becerra, S., ... & Kuhn, T. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1627.
A Case Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder and Major Depressive Disorder
Zielinski, M., Mahdavi, K., Jordan, S., Haroon, J., Habelhah, B., Beccera, S., ... & Kuhn, T. Bystrisky, A. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1667.
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Mahdavi, K. D., Jordan, S. E., Barrows, H. R., Pravdic, M., Habelhah, B., Evans, N. E., ... & Kuhn, T. (2021). Neurology: Clinical Practice, 11(3), e294-e302.
A case of COVID-encephalopathy imaged with fMRI and treated with near infrared light
Haroon, J., Mahdavi, K., Zielinski, M. A., Habelhah, B., Chan, L., Bystritsky, A., ... & Jordan, S. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation.
Smaller limbic structures are associated with greater immunosuppression in over 1000 HIV-infected adults across five continents: Findings from the ENIGMA-HIV Working Group.
Talia Nir, Jean-Paul Fouche, Jintanat Ananworanich, Beau Ances, Jasmina Boban, et al.. (2021)
Tumor location and reduction in functional MRI estimates of language laterality
Połczyńska MM, Beck L, Kuhn T, Benjamin CF, Ly TK, Japardi K, Cavanagh L, Bookheimer SY. (2021). J Neurosurg.
Brain Circuitry Underlying the ABC Model of Anxiety
Bystritsky, A., Spivak, N.M., Dang, B.H., Becerra, S.A., Distler, M.G., Jordan, S.E., & Kuhn, T.P. (2021). Journal of Psychiatric Research.
Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV
Nir, T. M., Fouche, J. P., Ananworanich, J., Ances, B. M., Boban, J., Brew, B. J., ... & Jahanshad, N. (2021). JAMA network open.