RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Smaller limbic structures are associated with greater immunosuppression in over 1000 HIV-infected adults across five continents: Findings from the ENIGMA-HIV Working Group.
Talia Nir, Jean-Paul Fouche, Jintanat Ananworanich, Beau Ances, Jasmina Boban, et al.. (2021)
Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV
Nir, T. M., Fouche, J. P., Ananworanich, J., Ances, B. M., Boban, J., Brew, B. J., ... & Jahanshad, N. (2021). JAMA network open.
Effects of Diffusion MRI Model and Harmonization on the Consistency of Findings in an International Multi-cohort HIV Neuroimaging Study.
Nir, T. M., Lam, H. Y., Ananworanich, J., Boban, J., Brew, B. J., Cysique, L., Fouche, J. P., Kuhn, T., Porges, E. S., Law, M., Paul, R. H., Thames, A., Woods, A. J., Valcour, V. G., Thompson, P. M., Cohen, R. A., Stein, D. J., & Jahanshad, N. (2019). Computational Diffusion MRI .
Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study
Jones JD, Kuhn T, Levine A, Sacktor N, Munro CA, Teplin LA, D'Souza G, Martin EM, Becker JT, Miller EN, Hinkin CH. (2019). Neuropsychology.
Effects of social adversity and HIV on subcortical shape and neurocognitive function
Thames, A. D., Kuhn, T. P., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2018). Brain imaging and behavior.
Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV
Anderson AE, Jones JD, Thaler NS, Kuhn TP, Singer EJ, Hinkin CH. (2018). Neuropsychology.
An Augmented Aging Process in Brain White Matter in HIV
Kuhn, T., Kaufmann, T., Doan, N.T., Westlye, L.T., Jones, J., Nunez, R.A., Bookheimer, S.Y., Singer, E.J., Hinkin, C.H., Thames, A.D. (2018). Human Brain Mapping.
Differential relationships between social adversity and depressive symptoms by HIV-status and racial/ethnic identity
Williamson, T. J., Mahmood, Z., Kuhn, T., & Thames, A. D. (2017). Health Psychology.
Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults
Thames, A. D., Kuhn, T., Williamson, T. J., Jones, J. D., Mahmood, Z., & Hammond, A. (2017). Drug and Alcohol Dependence.
Effects of Social Adversity and HIV on Subcortical Shape and Neurocognitive Function
Thames, A. D., Kuhn, T., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2017). Brain Imaging and Behavior.
Longitudinal Intra-Individual Variability in Neuropsychological Performance Relates to White Matter Changes in HIV
Jones, J. D., Kuhn, T., Mahmood, Z., Singer, E. J., Hinkin, C. H., Thames, A. D. (2017). Neuropsychology.
Medication Adherence in HIV-Positive African Americans: The Roles of Age, Health Beliefs, and Sensation Seeking
Sayegh P, Thaler NS, Arentoft A, Kuhn TP, Schonfeld D, Castellon SA, Durvasula RS, Myers HF, Hinkin CH. (2016). Cogent Psychol.
Combined effects of HIV and marijuana use on neurocognitive functioning and immune status
Thames AD, Mahmood Z, Burggren AC, Karimian A, Kuhn TP. (2016). AIDS Care. 28(5):628-32.
The Effects of HIV and Aging on Subcortical Shape Alterations: A 3D Morphometric Study.
Kuhn, T.,Schonfeld, D., Sayegh, P., Jones, J.D., Arentoft, A., Hinkin, C.H., Bookheimer, S.Y., & Thames, A.D. (2016). Human Brain Mapping. DOI 10.1002/hbm.23436