RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Connectivity-based parcellation of the amygdala and identification of its main white matter connections.
Avecillas-Chasin, J. M., Levinson, S., Kuhn, T., Omidbeigi, M., Langevin, J. P., Pouratian, N., & Bari, A. (2023). Scientific reports, 13(1), 1305.
Asylum Medicine Training Initiative: Asylum Medicine Introductory Curriculum
Saadi A., Khoury M., Dietiker C., Mass A., Jacquemet N., & Kuhn T. (2022). Module 8: Traumatic Brain Injury. In Emery E., DeFries T. (2022). Panopto. https://pro.panopto.com/Panopto/Pages/Viewer.aspx?tid=9009e2b9-7ae6-4b7b- 91e0-aed80111c48e
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series
Rindner, E., Haroon, J., Jordan, K., Mahdavi, K., Surya, J. R., Zielinski, M., Habelhah, B., Venkatraman, V., Becerra, S., Chan, L., Kuhn, T., & Jordan, S. (2022). Journal of Lasers in Medical Sciences, 13, e65.
Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study
Zielinski, M. A., Evans, N. E., Bae, H., Kamrava, E., Calodney, A., Remley, K., ... & Jordan, S. (2022). Pain Physician, 25(1), 29.
A Structural Connectivity Atlas of Limbic Brainstem Nuclei
Levinson, S., Miller, M., Iftekhar, A., Arriola, D., Hazany, S., Avecillas-Chasin, J., ... & Bari, A. A. (2022). bioRxiv.
Intraindividual Variability in Neuropsychological Performance Predicts Longitudinal Cortical Volume Loss in Early Parkinson’s Disease
Jones, J. D., Valenzuela, Y. G., Uribe, C., Bunch, J., & Kuhn, T. P. Neuropsychology.
The Role of the Insula in Classical and Dissociative PTSD: A Double Case Study
Blades, R., Becerra, S., Jordan, S., Eusebio, B., Heatwole, M., Iovine, J., ... & Kuhn, T. (2022). Neurocase, 1-9.
Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy
Stern JM, Spivak NM, Becerra S, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, & Bystritsky A. (2021). Brain Stimulation.
Histological Examination of Transcranial Focused Ultrasound Effects on Human Brain Tissue
Spivak NM, Korb AS, Reyes SD, Bych BP, Schafer SF, Khanlou N, Johnson EA, Schafer ME, Cohen MS, Kuhn T, & Bystritsky A. Brain Stimulation. 2021; 14(6):1486-8. DOI: 10.1016/j.brs.2021.09.015. PubMed PMID: 34607066
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Mahdavi, K. D., Jordan, S. E., Barrows, H. R., Pravdic, M., Habelhah, B., Evans, N. E., ... & Kuhn, T. (2021). Neurology: Clinical Practice, 11(3), e294-e302.
A case of COVID-encephalopathy imaged with fMRI and treated with near infrared light
Haroon, J., Mahdavi, K., Zielinski, M. A., Habelhah, B., Chan, L., Bystritsky, A., ... & Jordan, S. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation.
Smaller limbic structures are associated with greater immunosuppression in over 1000 HIV-infected adults across five continents: Findings from the ENIGMA-HIV Working Group.
Talia Nir, Jean-Paul Fouche, Jintanat Ananworanich, Beau Ances, Jasmina Boban, et al.. (2021)
Tumor location and reduction in functional MRI estimates of language laterality
Połczyńska MM, Beck L, Kuhn T, Benjamin CF, Ly TK, Japardi K, Cavanagh L, Bookheimer SY. (2021). J Neurosurg.
Brain Circuitry Underlying the ABC Model of Anxiety
Bystritsky, A., Spivak, N.M., Dang, B.H., Becerra, S.A., Distler, M.G., Jordan, S.E., & Kuhn, T.P. (2021). Journal of Psychiatric Research.
Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV
Nir, T. M., Fouche, J. P., Ananworanich, J., Ances, B. M., Boban, J., Brew, B. J., ... & Jahanshad, N. (2021). JAMA network open.
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Kennedy D. Mahdavi, Sheldon E. Jordan, Hannah R. Barrows, Maša Pravdic, Barshen Habelhah, Natalie E. Nicodemus, Robin B. Blades, Jessica J. Iovine, Sergio A. Becerra, Rachel A. Steiner, Marisa Chang, Santosh Kesari, Alexander Bystritsky, Ed O'Connor, Hyman Gross, F. Scott Pereles, Mike Whitney, Taylor Kuhn. (2020). Neurology.
Neurogenic Thoracic Outlet Syndrome and other Forms of Cervical Brachial Syndrome Treated with Plasma Concentrate Enriched for Alpha 2 Macroglobulin
Jordan S, Iovine J, Kuhn T, Gelabert H. (2020). Pain Physician.
Episodic and Semantic Memory Disorders
Bauer R.M., Gaynor L., Moreno C., Kuhn T. (2019). In: Ravdin L., Katzen H. (eds) Handbook on the Neuropsychology of Aging and Dementia. Clinical Handbooks in Neuropsychology.
Case report: Improved rTMS efficacy after fMRI localizes DLPFC target to non-dominant hemisphere
Iovine, J. & Spivak, Norman & Jordan, S. & Mahdavi, Kennedy & Duncan, J. & Becerra, S. & Packham, H. & Nicodemus, N. & Pereles, S. & Whitney, M. & Bystrisky, A. & Kuhn, Taylor & Mamoun, Michael. (2019). Brain Stimulation.