RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Translating State-of-the-art Brain Magnetic Resonance Imaging (MRI) Techniques into Clinical Practice: Multimodal MRI Differentiates Dementia Subtypes in a Traditional Clinical Setting
Kuhn, T., Becerra, S., Duncan, J., Spivak, N., Dang, B. H., Habelhah, B., ... & Jordan, S. E. (2021). Quantitative Imaging in Medicine and Surgery, 11(9), 4056.
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Mahdavi, K. D., Jordan, S. E., Barrows, H. R., Pravdic, M., Habelhah, B., Evans, N. E., ... & Kuhn, T. (2021). Neurology: Clinical Practice, 11(3), e294-e302.
Treatment of dementia with bosutinib: An open-label study of a tyrosine kinase inhibitor
Kennedy D. Mahdavi, Sheldon E. Jordan, Hannah R. Barrows, Maša Pravdic, Barshen Habelhah, Natalie E. Nicodemus, Robin B. Blades, Jessica J. Iovine, Sergio A. Becerra, Rachel A. Steiner, Marisa Chang, Santosh Kesari, Alexander Bystritsky, Ed O'Connor, Hyman Gross, F. Scott Pereles, Mike Whitney, Taylor Kuhn. (2020). Neurology.
Episodic and Semantic Memory Disorders
Bauer R.M., Gaynor L., Moreno C., Kuhn T. (2019). In: Ravdin L., Katzen H. (eds) Handbook on the Neuropsychology of Aging and Dementia. Clinical Handbooks in Neuropsychology.
Focused transcranial ultrasound for treatment of neurodegenerative dementia
Nicodemus, N. E., Becerra, S., Kuhn, T. P., Packham, H. R., Duncan, J., Mahdavi, K., ... & Jordan, S. Alzheimer's & Dementia: Translational Research & Clinical Interventions. (2019)
Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort
Jones JD, Kurniadi NE, Kuhn TP, Szymkowicz SM, Bunch J, Rahmani E. (2019). Neuropsychology.
The Lifespan Human Connectome Project in Aging: An overview.
Bookheimer SY, Salat DH, Terpstra M, Ances BM, Barch DM, Buckner RL, Burgess GC, Curtiss SW, Diaz-Santos M, Elam JS, Fischl B, Greve DN, Hagy HA, Harms MP, Hatch OM, Hedden T, Hodge C, Japardi KC, Kuhn TP, Ly TK, Smith SM, Somerville LH, Uğurbil K, van der Kouwe A, Van Essen D, Woods RP, Yacoub E. (2019). Neuroimage.
An Augmented Aging Process in Brain White Matter in HIV
Kuhn, T., Kaufmann, T., Doan, N.T., Westlye, L.T., Jones, J., Nunez, R.A., Bookheimer, S.Y., Singer, E.J., Hinkin, C.H., Thames, A.D. (2018). Human Brain Mapping.
The Effects of HIV and Aging on Subcortical Shape Alterations: A 3D Morphometric Study.
Kuhn, T.,Schonfeld, D., Sayegh, P., Jones, J.D., Arentoft, A., Hinkin, C.H., Bookheimer, S.Y., & Thames, A.D. (2016). Human Brain Mapping. DOI 10.1002/hbm.23436