RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Focused ultrasound as a potential means of facilitated exosome delivery to brodmann area 25 in the treatment of refractory depression
Mahdavi, Kennedy & Packham, H. & Nicodemus, N. & Jordan, S. & Iovine, J. & Duncan, J. & Becerra, S. & Spivak, Norman & Kuhn, Taylor & Whitney, M. & Mamoun, Michael. (2019). Brain Stimulation.
Effects of Diffusion MRI Model and Harmonization on the Consistency of Findings in an International Multi-cohort HIV Neuroimaging Study.
Nir, T. M., Lam, H. Y., Ananworanich, J., Boban, J., Brew, B. J., Cysique, L., Fouche, J. P., Kuhn, T., Porges, E. S., Law, M., Paul, R. H., Thames, A., Woods, A. J., Valcour, V. G., Thompson, P. M., Cohen, R. A., Stein, D. J., & Jahanshad, N. (2019). Computational Diffusion MRI .
Variations in targeting techniques of focused ultrasound for use in neuromodulation
Spivak, N. M., & Kuhn, T. P. (2019). Brain stimulation.
Focused transcranial ultrasound for treatment of neurodegenerative dementia
Nicodemus, N. E., Becerra, S., Kuhn, T. P., Packham, H. R., Duncan, J., Mahdavi, K., ... & Jordan, S. Alzheimer's & Dementia: Translational Research & Clinical Interventions. (2019)
Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort
Jones JD, Kurniadi NE, Kuhn TP, Szymkowicz SM, Bunch J, Rahmani E. (2019). Neuropsychology.
Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study
Jones JD, Kuhn T, Levine A, Sacktor N, Munro CA, Teplin LA, D'Souza G, Martin EM, Becker JT, Miller EN, Hinkin CH. (2019). Neuropsychology.
The Lifespan Human Connectome Project in Aging: An overview.
Bookheimer SY, Salat DH, Terpstra M, Ances BM, Barch DM, Buckner RL, Burgess GC, Curtiss SW, Diaz-Santos M, Elam JS, Fischl B, Greve DN, Hagy HA, Harms MP, Hatch OM, Hedden T, Hodge C, Japardi KC, Kuhn TP, Ly TK, Smith SM, Somerville LH, Uğurbil K, van der Kouwe A, Van Essen D, Woods RP, Yacoub E. (2019). Neuroimage.
Effects of social adversity and HIV on subcortical shape and neurocognitive function
Thames, A. D., Kuhn, T. P., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2018). Brain imaging and behavior.
Effects of fMRI navigated TMS on treatment outcomes in major depressive disorder
Packham, H.R. & Nicodemus, N.E. & Jordan, S.E. & Whitney, M. & Pereles, F.S. & Duncan, J.C. & Becerra, S.B. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.
Utilizing fMRI correlates of cognitive reappraisal to identify additional TMS targets for the treatment of GAD
Nicodemus, N.E. & Packham, H.R. & Jordan, S.E. & Whitney, M. & Pereles, S. & Duncan, J.C. & Becerra, S.A. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.
Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV
Anderson AE, Jones JD, Thaler NS, Kuhn TP, Singer EJ, Hinkin CH. (2018). Neuropsychology.
An Augmented Aging Process in Brain White Matter in HIV
Kuhn, T., Kaufmann, T., Doan, N.T., Westlye, L.T., Jones, J., Nunez, R.A., Bookheimer, S.Y., Singer, E.J., Hinkin, C.H., Thames, A.D. (2018). Human Brain Mapping.
Assessment of grammar optimizes language tasks for the intracarotid amobarbital procedure
Połczyńska M, Kuhn T, You SC, Walshaw P, Curtiss S, Bookheimer S. (2017). Epilepsy Behav.
Improving language mapping in clinical fMRI through assessment of grammar
Połczyńska M, Japardi K, Curtiss S, Moody T, Benjamin C, Cho A, Vigil C, Kuhn T, Jones M, Bookheimer S. (2017). Neuroimage Clin.
Improvements in Brain and Behavior Following Eradication of Hepatitis C
Kuhn, T.P., Sayegh, P., Jones, J.D., Smith, J., Sarma, M.K., Ragin, A., Singer, E.J., Thomas, A., Thames, A.D., Castellon, S.A., Hinkin C.H. (2017). Journal of Neurovirology, 23(4), 593-602.
The Neuropsychology Fact-Finding Casebook: A Training Resource
Kuhn, T., & Springate, B. A. (2017). Archives of Clinical Neuropsychology, 1-3.
Differential relationships between social adversity and depressive symptoms by HIV-status and racial/ethnic identity
Williamson, T. J., Mahmood, Z., Kuhn, T., & Thames, A. D. (2017). Health Psychology.
Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults
Thames, A. D., Kuhn, T., Williamson, T. J., Jones, J. D., Mahmood, Z., & Hammond, A. (2017). Drug and Alcohol Dependence.
Effects of Social Adversity and HIV on Subcortical Shape and Neurocognitive Function
Thames, A. D., Kuhn, T., Mahmood, Z., Bilder, R. M., Williamson, T. J., Singer, E. J., & Arentoft, A. (2017). Brain Imaging and Behavior.
Longitudinal Intra-Individual Variability in Neuropsychological Performance Relates to White Matter Changes in HIV
Jones, J. D., Kuhn, T., Mahmood, Z., Singer, E. J., Hinkin, C. H., Thames, A. D. (2017). Neuropsychology.